Gabapentin modulates the action of glutamate decarboxylase (gad) and branched chain aminotransferase (best), two enzymes involved in GABA biosynthesis. As the GABA system is the most prolific inhibitory receptor set within the brain, its increase in biosynthesis results in the sedating and anxiolytic (or calming effects) of gabapentin on the nervous system. The starting dose usually used ranges from 100 mg up to 1200 mg of Gabapentin per day, to be taken in divided doses according to medical indications. After that, the amount of drug administered can be gradually increased by the doctor up to a maximum of 1600 mg of Gabapentin per day.
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