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Vardenafil and other PDE5 inhibitors help treat ED by allowing more blood to flow to your penis. To understand how these drugs work, it helps to understand the erection process.

  1. Once you become sexually aroused, your brain sends a message to the blood vessels in your penis to release a chemical called nitric oxide
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  4. Nitric oxide diffuses inside your blood vessels and stimulates the formation of another molecule called cGMP.
  5. cGMP relaxes the blood vessels in your penis and allows more blood to flow into its tissues.

Vardenafil inhibits the enzyme PDE5 that breaks down cGMP. Inhibiting this enzyme increases the amount of cGMP available in your blood vessels and allows more blood to flow to your penis.

Along with treating ED, some types of PDE5 inhibitors are also used to treat a condition called pulmonary hypertension.

Can vardenafil treat all forms of ED?

ED is a multifaceted condition with many potential causes such as:

  • poor circulation
  • hormonal imbalances
  • nerve dysfunction
  • stress
  • anxiety
  • depression

Vardenafil and other PDE5 inhibitors are often the first-line treatment for treating ED when physical causes are suspected.

For example, it may be effective if poor circulation linked to diabetes or cardiovascular disease

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