Tapentadol is a centrally acting analgesic (pain reliever) medication used to treat moderate to severe acute pain, such as pain following surgery or injury, as well as chronic pain conditions like neuropathic pain. It works by acting on opioid receptors in the brain and by inhibiting the reuptake of norepinephrine, a neurotransmitter involved in pain signaling.

Tapentadol is considered a novel analgesic because it combines two mechanisms of action: mu-opioid receptor agonism and norepinephrine reuptake inhibition. This dual action helps to provide pain relief while potentially reducing the side effects associated with traditional opioids.

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